antinociceptive effect of oral and intraperitoneal administration of alcoholic viscum album fruit extract in male rats
نویسندگان
چکیده
objective: the present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic viscum album (v.a) fruit extract as a rich source of alkaloid substances. materials and methods: experimented animals were divided into control and treatment groups. the treatment rats received different doses of the v.a fruit extract, which was prepared from alcoholic smashed fruits. then, the animals from each group were subjected to pain scoring experiments such as hot plate and formalin tests. results: the results of the experiments i.e., antinociceptive effect of i.p. v.a extract (50, 100 and 200 mg/kg) and oral application method v.a (6.25% food pellet) were compared with others and morphine sulfate and naloxone as positive and negative control groups, respectively. the extract at doses over than 100 mg/kg (i.p.) could potentially alleviate the pain in hot plate and both phases of the formalin test. besides, there was a marked antinociceptive effect of the extract (over than 200 mg/kg) in oral method in hot plate and both phases of the formalin tests. meanwhile, the effective doses of morphine sulfate as positive control were observed at doses over than 15 mg/kg (i.p.). conclusion: in summary, by comparing the analgesic effect of different doses of morphine sulfate with v.a fruit extract in i.p and oral conditions and regarding to the extract ld50, it is concluded that the v.a fruit extract has a potent, semi-absorbable, and nearly safe ingredient which can exert a potential analgesic effect in acute and chronic painin summery, by comparing the analgesic effect of different doses of morphine sulfate with v.a fruit extract in i.p and oral conditions and regarding to the extract ld50, it is concluded that the v.a fruits extract have a potent, semi-absorbable, and nearly safe ingredient which can exert a potential analgesic effect in acute and chronic pain.
منابع مشابه
Antinociceptive Effect of Oral and Intraperitoneal Administration of Alcoholic Viscum Album Fruit Extract in Male Rats
Objective: The present study was designed to investigate the analgesic effect of oral and i.p. administration of alcoholic Viscum album (V.A) fruit extract as a rich source of alkaloid substances. Materials and Methods: Experimented animals were divided into control and treatment groups. The treatment rats received different doses of the V.A fruit extract, which was prepared from alcoholic sma...
متن کاملAntinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats
The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...
متن کاملAntinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats
The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...
متن کاملAntinociceptive effects of oral and intraperitoneal administration of alcoholic Datura stramonium seeds extract in male rats
The present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic Datura stramonium (DS) seed extract as a rich source of alkaloid substances. Male NMRI rats were divided into control and treatment groups. The treatment rats received different doses of the DS seed extract, which was prepared from alcoholic smashed s...
متن کاملantinociceptive effects of oral and intraperitoneal administration of alcoholic datura stramonium seeds extract in male rats
the present study is a designed protocol for investigation of the analgesic effect of oral and intraperitoneal (i.p.) administration of alcoholic datura stramonium (ds) seed extract as a rich source of alkaloid substances. male nmri rats were divided into control and treatment groups. the treatment rats received different doses of the ds seed extract, which was prepared from alcoholic smashed s...
متن کاملthe effect of aqueous extract of garlic on formalin-induced pain in male rats
چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...
15 صفحه اولمنابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
journal of basic and clinical pathophysiologyناشر: shahed university
ISSN 2322-1895
دوره 3
شماره 1 2015
کلمات کلیدی
میزبانی شده توسط پلتفرم ابری doprax.com
copyright © 2015-2023